GH BLAST^TM: Effervescent Cellular Supercompensation

The following article explains the scientific rationale behind the effervescent cellular loading system and the active ingredients found in X-TREME GH Blast.

Effervescent cellular loading is thought to trigger protein synthesis and thus lead to anabolism. Iron Curtain Labs (ICL) is one of the first supplement companies to combine effervescence and osmotic cellular loading in order to achieve cellular supercompensation. Cellular supercompensation is the ability to absorb and store more than the normal amount of a substance inside the cell. X-TREME GH Blast utilizes natural hormonal manipulation coupled with a novel drug delivery system in order to enhance the amount and rate of nutrient absorption.

The anabolic hormone Insulin is thought to be one of the factors regulating protein synthesis. Insulin (the gatekeeper hormone) also allows carbohydrates and proteins to enter the cell. X-TREME GH Blast has incorporated a mild amount of simple carbohydrate in order to utilize natural hormonal manipulation for the purpose of enhancing absorption. The ingestion of simple carbohydrate elicits an insulin response, which helps to promote the absorption of the active amino acids found in the formula.

The novel drug delivery system utilized in X-TREME GH Blast is effervescence. Effervescence or CO2 carbon dioxide bubbling has been utilized for several years in many OTC drugs in order to increase ingredient permeability.

1 Effervescence has the ability to increase the rate of absorption into the small intestine. It performs this function by altering the pH of the stomach. The effervescence first creates zwitterion molecules with the active ingredients. Zwitterion molecules contain both a positive and negative charge. The effervescence and bicarbonate then raise the pH of the stomach allowing the ingredients to enter the small intestine at much faster than normal rate.

2 The faster the active ingredients enter the small intestine the faster they can enter the blood stream and perform their functions. Osmotic cellular loading is the shift of fluid volume from a lesser concentration to a greater concentration. In other words, when a high solute load of creatine, L-glutamine, glycine and taurine is consumed and stored inside the muscle cell it causes a shift of extracellular fluid to intracellular fluid.

3 The fluid follows the solute load of amino acids into the muscle cell thereby increasing cell volume. The addition of insulin manipulation and effervescence promotes the amount and rate of amino acid absorption thus allowing for a greater than normal amount of solute to enter the cell. This greater than normal amount of solute produces cellular supercompensation or super charged cell volumzing. The increased water volume inside the muscle is thought to stretch the cells and activate protein synthesis. The activation of protein synthesis may have the ability to promote anabolism and fat free mass. The increase in intracellular fluid may also have an aesthetic appeal by making the muscle appear to be fuller or larger. The first and most well known ingredient is creatine monohydrate (CM). CM has been shown to promote recovery, endurance, strength and fat free mass.

4 CM performs the first three functions by increasing the rate of ATP resynthesis.

5 ATP or adenosine triphosphate is the perfered energy source during quick explosive energy bouts. CM is stored inside the muscle as creatine phosphate (CP). Once ATP is used it loses a phosphate and becomes ADP or adenosine diphosphate. In order for it to become ATP again it must borrow a phosphate. ADP now has a steady source of phosphate due to the CP stored inside the muscle. ADP can recycle itself back to ATP at a much faster rate due to the extra phosphate. This increased ATP recycling has been shown to responsible for the promotion recovery, endurance and strength. The increase in fat free mass is due to the cellular volumizing theory previously mentioned. L-Glutamine is the next ingredient found in GH Blast and probably the second most well known amino acid in sport nutrition. L-Glutamine is known as the conditionally essential amino acid due to its anti-catabolic properties.

6 The stress of intense training and or competition dieting may cause L-Glutamine levels to decline resulting in a loss of muscle mass.

7 Adequate L-Glutamine levels are necessary for the maintenance of nitrogen balance and protein synthesis. L-Glutamine also contributes to cellular volumizing thus creating a greater solute load. The amino acid Glycine may also contribute to cellular volumizing but more importantly may promote actual growth hormone release from the pituitary gland.

8 Glycine has been shown in oral human studies to promote the release of growth hormone.

9 Growth Hormone is a powerful compound that can favorably alter body composition. Growth Hormone may also contribute to protein synthesis and anabolism in weight training individuals. Taurine is an amino acid thought to regulate cellular volume and have the ability to improve the action of insulin. Taurine may have the ability to promote insulin sensitivity.

10 This improved metabolic function could then allow for better uptake of the solute load and contribute to cellular supercompensation. Taurine has also been shown in animal studies to increase production of nitric oxide.

11 Nitric oxide is involved in many metabolic functions in the body. Nitric oxide appears to regulate protein synthesis and nitrogen retention thus possibly leading to anabolism. Alpha lipoic acid (ALA) has been incorporated into the formula in order to work synergistically with Taurine. ALA, a naturally occuring compound and a radical scavenger was shown to enhance glucose transport and utilization in different experimental and animal models.

12 ALA works similar to Taurine by promoting insulin sensitivity

13. Together they may enhance the natural insulin manipulation in order to improve absorption of the amino acid load. D-Ribose is the newest compound in the formula. D-Ribose is 5-carbon pentose sugar molecule. It's a natural intermediate of carbohydrate metabolism. D-Ribose provides substrate for the formation of adenine nucleotides. These nucleotides are responsible for the formation of ATP. Intense training or hypocaloric intake decreases the nucleotide levels in the body thus slowing down ATP resynthesis.

14 The supplementation of D-Ribose provides the body with adequate nucleotide levels thereby ensuring efficient ATP resynthesis.

15 D-Ribose is also converted to 5-ribose phosphate, which increases phosphate stores similar to creatine. A recent study utilizing oral supplemental D-Ribose was shown to increase peak power and mean power output.

16 This is the first in hopefully many studies showing D-ribose to be the next great high energy supplement of the bodybuilding industry. X-TREME GH Blast has decided to combine D-ribose with creatine, l-glutamine, and taurine in order produce phenomenal results.

In conclusion, The X-TREME GH BLAST is an effervescent cellular loading system designed to promote anabolism and cellular supercompensation. This unique formula may have the ability to promote strength, muscle recovery, and fat free mass when combined with a proper weight-training program. The effervescent delivery system forms zwitterion molecules and increases the pH of the stomach, which dramatically promotes the rate of absorption into the small intestine. Creatine Monohydrate allows the body to increase the rate of ATP resynthesis. It performs this process by providing the body with extra phosphate thus allowing for faster recovery and increased workout intensity. The L-Glutamine acts as an anti-catabolic and promotes cell volumizing, which is thought to activate protein synthesis. Glycine is amino acid that may promote the release of growth hormone from the pituitary gland. The Taurine and Alpha Lipoic Acid work by promoting insulin sensitivity in order to further enhance the cellular loading. D-Ribose is a new high-energy compound that may promote muscle recovery and endurance. X-TREME GH BLAST is an ideal supplement for any bodybuilder or athlete attempting to promote anabolism and cellular supercompensation.

References

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7. Hickson, RC. Et al. 1995. Glutamine prevents downregulation of myosin heavy chain synthesis and muscle atrophy from glucocorticoids Am J Physiol. Apr;268(4 Pt 1):E730-740.

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9. Kasi, K. Et al. 1980. Glycine stimulated growth hormone release in man Acta Endocrinol (Copenh). Mar; 93(3): 283-286.

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13. Hellsten-Westing, Y. et al. 1993. Decreased resting levels of adenine nucleotides in Human skeletal muscle after high-intensity training JAppl Physiol. 74(5): 2523-2528.

14. Tullson, P.C. and Terjung, R.L. 1991. Adenine nucleotide synthesis in exercising and endurance trained skeletal muscle Am J Physiol. 261(Cell Physiol.30): C342- C347.

15. Ziegenfuss, T. 1999. The effects of Ribocell supplementation on repeated sprint performance: A Pilot Study. American College of Sports Medicine 47th Annual Meeting. Submitted for publication.