GH 1000 ®

Adaptive Hormonal Regenerating Agents

The following article is a scientific review of the compounds found in the latest product from (ICL) Iron Curtain Labs. The X-TREME GH 1000 ® is a unique combination of Anabolic Isoflavones, Herbs, Sterols and B Vitamins designed to promote vitamin - mineral / nitrogen retention, free or active testosterone levels, and regulate estrogen conversion. X-TREME GH 1000 ® represents the latest growth promoting compounds and is not designed to elicit an actual growth hormone response.

5-Methyl 7-Methoxy Isoflavone is considered to be a non-estrogenic anabolic isoflavone. It well known in the cattle industry that when cattle graze they usually consume some type of clover. These clovers contain phytoestrogens or plant estrogens. There are many different types of phytoestrogens ranging from flavones, isoflavones, and glycones.

1 These plant estrogens act like real estrogen in the cow and promote anabolism. Unfortunately some phtyoestrogens impart estrogen side effects such as water retention and fat storage. The phytoestrogen resembles the same chemical structure of estrogen and can fit inside the estrogen receptor. Once inside the estrogen receptor it will block the natural estrogen from binding.

1 Now depending upon the type of phytostrogen this could either increase or decrease the amount of estrogen absorbed by the body. Drug companies produce synthetic estrogen and estrogen / testosterone combinations in order to promote growth in cattle. It appears that back in the early 70's there was desire to create non-estrogenic anabolic isoflavone to use in place of synthetic estrogens for various unknown but greatly appreciated reasons.

To create a non-estrogenic, non-androgenic anabolic compound is no easy task and would be considered by many as the ideal anabolic compound. Thus a group of scientists from Budapest, Hungary set out and accomplished this goal. By using phytoestrogens as a starting block they were able to synthetically produce this new group of isoflavones. According to two early patents on animal feed these types of isoflavones increase calcium, magnesium, potassium, and nitrogen retention.

2 This increased retention of minerals and nitrogen may promote fat free mass gain in weight training individuals. Through the research conducted by the Hungarian scientists they were able to establish the promotion of anabolism free of androgenic effect. They also established that the weight increase of muscle tissue was far greater than fat tissue and that the fat content of the muscle tissue decreased. These same scientists found that these anabolic isoflavones had the same results in oral human doses.

3 The following compound deals with the promotion of testosterone and free or active testosterone. Avena Sativa is the Latin name for oat straw. This wild oat derivative has been shown to increase luteinizing hormone (LH).

4 When the body perceives that there is adequate amount of hormone it shuts down production of that hormone. The key to regenerating testosterone production is to stimulate LH. LH is responsible for the natural production of testosterone from the testes. Avena Sativa is also thought to have the unique ability to increase unbound or free testosterone. Unpublished research conducted by the Institute for Advanced Study of Human Sexuality has alluded to Avena Sativa's ability to increase unbound testosterone. Unbound or free testosterone is the portion of testosterone that exerts the anabolic and androgenic effects. The anabolic effect of testosterone deals with promotion of protein synthesis, nitrogen retention and blocking of cortisol at the receptor level. Bound testosterone is comprised of sex hormone binding globulin (SHBG) and albumin. This constitutes the majority of circulating testosterone in the body. The promotion of LH and total testosterone coupled with the promotion of free or active testosterone should result in dramatic effects. Whenever the body produces endogenous testosterone a portion of that testosterone is unbound and bound. The avena sativa promotes the amount of unbound testosterone resulting in an enhanced form of anabolic hormone.

Although testosterone is a wonderful muscle enhancer it also can produce negative effects. These negative effects are a result of testosterone conversion to estrogen and (DHT) Dihydrotestestosterone. Whether it's the production of natural or synthetic testosterone, a portion will convert to estrogen, which can lead to increased fat and water storage. Natural flavones have the ability to act as anti-aromatases and regulate this conversion. Certain flavones perform this action by inhibiting the enzyme responsible for the conversion. The key to preserving gains is to jump-start the natural production of LH and regulate estrogen conversion. This is why X-TREME GH 1000 ® has incorporated (DIM) Diidolylmethane, Quercetin, and a Beta-Sitosterol complex.

Diindolylmethane (DIM) is the active constitute or metabolite of (I3C) Indole-3-carbinol. I3C is a naturally occurring anti-aromatase component of cruciferous vegetables. When I3C is consumed it is converted to DIM in the gut. The only problem with I3C is the oral bioavailability. In other words, a great deal of the compound is destroyed in the gut. The direct supplementation of DIM provides an adequate amount of active compound. DIM has been shown to regulate estrogen by several different mechanisms. This means that it may have the ability to regulate the aromatization or conversion of testosterone to estrogen. Diindolylmethane in vivo has been shown to inhibit the Cytochrome P-450 enzyme responsible for this conversion.

5 This process is beneficial in preventing any negative side effects such as fat and water retention, which are usually associated with elevated estrogen levels. Quercetin is a naturally occurring flavanoid found in various foods. This flavone in vitro has been shown to regulate estrogen conversion and absorption. It appears that quercetin in vitro regulates estrogen conversion via the inhibition of the aromatase enzyme Cytochrome P-450.

6 The absorption of estrogen takes place at the estrogen receptor and the type II estrogen binding sites. Quercetin has been shown to regulate estrogen absorption in vitro by binding to the predominant type II estrogen binding sites.

7 Beta-Sitosterol is a phytosterol or plant sterol. Beta-Sitosterol is one of the main active ingredients found in Saw Palmetto berries. Saw Palmetto is an herb thought to help regulate DHT conversion. DHT can be produced from testosterone. DHT is responsible for the negative androgenic properties of testosterone. Testosterone is converted by the enzyme 5-alpha reductase into DHT. Beta-Sitosterol has the ability inhibit this enzyme thus regulating DHT conversion.

8 Research of phytosterol complexes with Beta-Sitosterol, as the primary ingredient has been positive in regards to DHT regulation.

9 A 5% standardized Ginger extract has been incorporated in an attempt to increase the overall bioavailability of X-TREME GH 1000 ®. Ayurvedic herbals commonly utilize peppers and ginger to increase the oral bioavailability of prescriptions in Ayurveda.

10 Researchers think these compounds increase the bioavailability of certain drugs by promoting rapid absorption from the gastrointestinal tract or by protecting the drug from being metabolized / oxidized in its first passage through the liver after absorption.

The final combination consists of a Vitamin B complex. Interestingly enough research is finding that intense training can lead to the depletion of various vitamins and minerals. This is why X-TREME GH 1000 ® has included Dimethylglycine (DMG), Vitamin B6 (pyridoxine) & Vitamin B12 (cyanocobalamin). (DMG) Dimethylglycine is an analog of pangamic acid or Vitamin B15. Chemically DMG, is a tertiary amino acid, which enhances oxygen utilization by tissue and complexes free radicals.

11 Physical exercise triggers the production of free radicals, which can partially be responsible for muscular damage. Intense training can also weaken an athlete's immune system leaving them vulnerable. DMG has been suggested to have the potential to help support a healthy immune system.

11 Vitamin B6 is involved in various metabolic functions such as gluconeogenesis, Vitamin B3 (Niacin) formation, lipid metabolism, red blood cell metabolism, and steroid function.

12 The requirement for B6 is primarily based upon protein intake. So in other words the more protein someone consumes the greater the B6 requirement. Vitamin B12 (cyanocobalamin) is involved in DNA synthesis, storage of folate in cells, fat – carbohydrate – protein metabolism, and acts as reducing agent.

12 In conclusion, the method of the present dietary supplement is to promote vitamin - mineral / nitrogen retention, regenerate production of naturally produced anabolic hormone and regulate estrogen conversion. The overall aim of this formula is to provide an effective supplement that supports growth promoting hormone secretion in order to maintain muscle recovery and growth from weight training. The notion of an anabolic dietary supplement that promotes strength and fat free mass can help to elevate some of the ethical dilemmas surrounding drug use in sports. Iron Curtain Labs is a diligent and dedicated company continually researching and developing the latest compounds in order to produce the highest quality bodybuilding supplements in the sports nutrition industry.

* These statements have not been evaluated by the FDA. This product is not intended to treat, diagnose, cure, or prevent any diseases.

REFERENCES

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3. Feuer, L Et al. U.S. Patent#3,949,085 1976. "Anabolic-weight gain promoting compositions containing isoflavone derivatives and method using same" April:p.1-12.

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11. Graber, CD. Et al. 1981. "Immunomodulating properties of dimethylglycine in humans" J Infect Dis. Jan; 143(1):p.101-105.

12. Shils, ES. Et al. 1994. "Modern Nutrition in health and Disease" Lea & Febiger. 8th Edition. Vol. 1; p.386-391; p.414-419.